Off-label & Investigational uses

By Jen Sarr, October 2nd, 2009 posted in Uncategorized - No Comments »

Lower back pain
Carisoprodol is a centrally acting muscle relaxant commonly used for back pain. In several studies it was found to be superior to placebo in relieving stiffness, increasing movement, and leading to general improvement. In comparative study carisoprodol was better than propoxyphene in relieving stiffness and increasing movement. In the other comparative study carisoprodol was superior to diazepam for relieving the symptoms of acute lower back pain.

The results of a double-blind study that compared carisoprodol, butabarbital, and placebo, have shown the effectiveness of carisoprodol in the treatment of the low back pain syndrome. Carisoprodol was found to be significantly more effective in providing both subjective pain relief and objective improvements in range of motion when evaluated by finger to floor testing. The results of this study suggest that the effects of carisoprodol are not secondary to its sedative effects alone, but are also related to its muscle relaxant activity.

Fibromyalgia
In a study of patients with fibromyalgia, carisoprodol compound (carisoprodol/paracetamol/caffeine) was found to be superior to placebo in alleviating pain, inducing sleep, and minimizing the general feeling of being sick.

History of Carisoprodol

By Jen Sarr, October 2nd, 2009 posted in Uncategorized - No Comments »

The misuse and abuse of meprobamate and other muscle relaxing drugs was an item of great concern in the 1950s and 1960s . Carisoprodol was developed in the 1950s by Dr. Frank M. Berger at Wallace laboratories on the basis of meprobamate, hoping that it would have better muscle-relaxing properties, less abuse potential, and less risk of overdose than meprobamate.

The substitution of one hydrogen atom with an isopropyl group on one of the carbamyl nitrogens was intended to yield a molecule with new pharmacological properties.

Initial pharmacokinetic studies using a canine model indicated that carisoprodol was metabolized to hydroxy-carisoprodol. The metabolism of carisoprodol to meprobamate was described in mice in 1969. But it was only after a description of a carisoprodol intoxication in 1976, that it was acknowledged that carisoprodol was mostly metabolized to meprobamate in humans.

Carisoprodol is sold in most countries. Some countries like Spain sell it over-the-counter, but in most countries a prescription is required.

Carisoprodol was approved for marketing before the FDA required that safety and efficacy be proved in clinical studies.

Pharmacy Reviews

Carisoprodol Information

By Jen Sarr, September 19th, 2009 posted in Uncategorized - No Comments »

Carisoprodol is a muscle relaxer that works by blocking pain sensations between the nerves and the brain.Carisoprodol is used together with rest and physical therapy to treat injuries and other painful musculoskeletal conditions.

Carisoprodol is a colorless, crystalline powder, having a mild characteristic odor and a bitter taste. It is slightly soluble in water. Its solubility is practically independent of ph.

Carisoprodol is marketed in the United States under the brand name Soma, and in the United Kingdom and other countries under the brand names Sanoma and Carisoma. Carisoprodol is especially useful against various types of pain (whether or not related to muscle spasm) because of its analgesic-sparing (potentiating) effect on opioid analgesics. Carisoprodol is available by itself or mixed with aspirin and in one preparation (Soma Compound With Codeine) along with codeine and caffeine as well